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KMID : 0861020170320050001
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Korea Journal of Herbology
2017 Volume.32 No. 5 p.1 ~ p.6
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Corni Fructus Inhibits Wrinkle Formation by Reduced Advanced glycation end product (AGEs)
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Lee Ah-Reum
Kim Soo-Hyun
Kim Su-Ji
Kim Kyeong-Jo
Kwon Oh-Jun
Choi Joon-Young
Roh Seong-Soo
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Abstract
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Objectives : Corni Fructus (CF) is traditional herbal medicine used on polyuria, low back pain, and tinnitus. This study aimed to evaluate inhibits skin wrinkle formation effect of CF.
Methods : To evaluate the produce inhibition effect of CF, SD-rats were distributed into four groups; normal rats (Nor), AGEs (advenced glycation end product)-induced rats (Con), AGEs-induced rats treated with 100㎎/㎏ CF (CF). To induce AGEs, streptozotocin (50㎎/㎏) was administered intraperitoneally and after 3 days oral administrated 100mM methyl glyoxal for 3 weeks.
Results : The oral administration of CF suppressed the reactive oxygen specis (ROS) in serum. The AGEs in skin tissues was significantly reduced through treatment of CF. Furthermore, the expressions of AGEs related proteins such as polyclonal anti-N e-(carboxymethyl)lysine (CML), anti-N e-(carboxyethyl)lysine (CEL), AGE receptors (RAGE) were decreased in CF treated group compared with the control group in skin tissues. Inflammation-related proteins such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) reduced in CF treatment group than control group. AGE-induced rats exhibited that the significant decreased collagen however, CF treatment (100㎎/㎏ of body weight) up regulated collagen by improved the expression levels of skin fibril-related genes such as Matrix metalloproteinase (MMP-1).
Conclusion : Taken together, our study suggests that CF regulates ROS to prevent accumulation of AGEs and inhibits skin wrinkles. Our finding indicate that CF may be an effective agent for inhibits AGEs formation, and improved skin wrinkle.
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KEYWORD
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Corni Fructus, wrinkle formation, collagen, Advanced glycation end product
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